Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 28 Jun 2013 Spain, Italy English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 340, pages 1,567-1,570 (issn: 0036-8075, eissn: 1095-9203,

Copyright policy )Funded by:EC | MRCA

Authors: Lapuente-Brun, Esther; Moreno-Loshuertos, Raquel; Acín-Pérez, Rebeca; Latorre-Pellicer, Ana; Colás, Carmen; Balsa, Eduardo; Perales-Clemente, Ester; +11 Authors

doi: 10.1126/science.1230381

pmid: 23812712

handle: 10261/129138 , 11577/3458450

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

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Abstract

Respiration Refined Cells derive energy from redox reactions mediated by mitochondrial enzymes that form the electron transport chain. The enzymes can form large complexes, known as supercomplexes, whose function has been controversial. Lapuente-Brun et al. (p. 1567 ) discovered that a mouse protein, supercomplex assembly factor I (SCAFI), specifically modulates assembly of respiratory complexes into supercomplexes. Formation of the supercomplexes appears to cause electrons to be processed differently, depending on the substrate from which they are derived.

Countries

Spain, Italy

Related Organizations

University of Padua
Italy
Autonomous University of Madrid
Spain
University of Zaragoza
Spain
Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa
Spain
Spanish National Research Council
Spain

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Keywords

Electron Transport Complex I, Ubiquinone, Molecular Sequence Data, Cytochromes c, Mitochondria, Electron Transport, Electron Transport Complex IV, Mice, Inbred C57BL, Electron Transport Complex III, Mice, HEK293 Cells, Amino Acid Sequence; Animals; Cells, Cultured; Cytochromes c; Electron Transport; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Gene Knockdown Techniques; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mitochondria; Molecular Sequence Data; Ubiquinone, Gene Knockdown Techniques, Animals, Humans, Amino Acid Sequence, Cells, Cultured

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