Probing Allostery Through DNA
Copyright policy )Probing Allostery Through DNA
Allostery Across DNA Proteins, such as transcription factors and RNA polymerase, bind close to each other on DNA and their function is coordinated. Kim et al. (p. 816 ; see the Perspective by Crothers ) report single-molecule experiments that show that the DNA binding affinity of a protein is significantly altered by a second protein bound nearby. The effect oscillates between stabilizing and destabilizing the binding with a periodicity equal to the helical pitch of DNA. Allosteric coupling between a transcriptional repressor and RNA polymerase modulated gene expression in living bacteria.
- Peking University China (People's Republic of)
- Harvard University United States
- Peking University China (People's Republic of)
- California Institute of Technology United States
570, Binding Sites, Base Sequence, Gene Expression, DNA-Directed RNA Polymerases, Gene Expression Regulation, Bacterial, Molecular Dynamics Simulation, 530, Nucleosomes, Protein Structure, Tertiary, DNA-Binding Proteins, Viral Proteins, Receptors, Glucocorticoid, Allosteric Regulation, Escherichia coli, Lac Repressors, DNA, B-Form, Protein Binding, Transcription Factors
570, Binding Sites, Base Sequence, Gene Expression, DNA-Directed RNA Polymerases, Gene Expression Regulation, Bacterial, Molecular Dynamics Simulation, 530, Nucleosomes, Protein Structure, Tertiary, DNA-Binding Proteins, Viral Proteins, Receptors, Glucocorticoid, Allosteric Regulation, Escherichia coli, Lac Repressors, DNA, B-Form, Protein Binding, Transcription Factors
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