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Optogenetic Control of Cardiac Function

descriptionPublicationkeyboard_double_arrow_right Article 12 Nov 2010 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 330, pages 971-974 (issn: 0036-8075, eissn: 1095-9203, Copyright policy )
Authors: Arrenberg, A.; Stainier, D.; Baier, H.; Huisken, J.;

doi: 10.1126/science.1195929

pmid: 21071670

handle: 21.11116/0000-0009-8917-3 , 21.11116/0000-0001-0BE4-2

Optogenetic Control of Cardiac Function

Abstract

A Steady Beat A regular heartbeat depends on steady function of the cardiac pacemaker. The early embryonic heart is neither as steady nor as organized as the mature heart. Arrenberg et al. (p. 971 ) used zebrafish engineered to express light-sensitive proteins to locate and manipulate the function of the cardiac pacemaker. By controlling the activity of small patches of cells with light beams, the authors monitored the development of the young heart, showing how the cardiac pacemaker develops during embryogenesis.

Related Organizations
Keywords

Rhodopsin, Embryo, Nonmammalian, Light, Embryonic Development, Heart, Myocardial Contraction, Heart Arrest, Animals, Genetically Modified, Heart Conduction System, Heart Rate, Tachycardia, Bradycardia, Animals, Myocytes, Cardiac, Atrioventricular Block, Halorhodopsins, Zebrafish, Sinoatrial Node

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    		 422
    popularity
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    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
422
Top 1%
Top 1%
Top 1%
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