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Was Adenine the First Purine?

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1989Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 245, pages 1,102-1,104 (issn: 0036-8075, eissn: 1095-9203,

Authors: Alan W. Schwartz; C. G. Bakker;

doi: 10.1126/science.11538344 , 10.1016/0168-9525(89)90193-5

pmid: 11538344

Was Adenine the First Purine?

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Abstract

Oligomerization of HCN (1 molar) in the presence of added formaldehyde (0.5 molar) produced an order of magnitude more 8-hydroxymethyladenine than adenine or any other biologically significant purine. This result suggests that on the prebiotic Earth, nucleoside analogs may have been synthesized directly in more complex mixtures of HCN with other aldehydes.

Related Organizations

Radboud University Nijmegen
Netherlands
Ege University
Turkey

Keywords

Aldehydes, Polymers, Purines, Adenine, Formaldehyde, Hydrogen Cyanide, Hydrolysis, Nucleosides

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	45
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average