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A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

descriptionPublicationkeyboard_double_arrow_right Article 07 Jan 2005 United Kingdom English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 307, pages 82-86 (issn: 0036-8075, eissn: 1095-9203,

Authors: Kim Rutherford; Carol Churcher; Robert E. Sinden; Doug Ormond; Laurence Florens; Fotis C. Kafatos; Bart Barrell; +25 Authors

doi: 10.1126/science.1103717

pmid: 15637271

A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

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Abstract

Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.

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United Kingdom

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Keywords

Proteomics, Life Cycle Stages, Plasmodium, Proteome, Plasmodium berghei, Gene Expression Profiling, Genes, Protozoan, Plasmodium falciparum, Protozoan Proteins, Computational Biology, Plasmodium yoelii, Malaria, Evolution, Molecular, Plasmodium chabaudi, Anopheles, Animals, Gene Silencing, 3' Untranslated Regions, Genome, Protozoan, Oligonucleotide Array Sequence Analysis

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