Ultraconserved Elements in the Human Genome
Copyright policy )Ultraconserved Elements in the Human Genome
There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in RNA processing or in introns or nearby genes involved in the regulation of transcription and development. Along with more than 5000 sequences of over 100 bp that are absolutely conserved among the three sequenced mammals, these represent a class of genetic elements whose functions and evolutionary origins are yet to be determined, but which are more highly conserved between these species than are proteins and appear to be essential for the ontogeny of mammals and other vertebrates.
- University of Queensland Australia
- University of Queensland Australia
- Howard Hughes Medical Institute United States
- University of California, Santa Cruz United States
- University of Queensland Australia
Identification, 572, Mouse, Evolution, Molecular Sequence Data, Noncoding Sequences, Gene, Evolution, Molecular, Mice, C1, Dogs, Animals, Humans, 270202 Genome Structure, Conserved Sequence, Genetics & Heredity, Conserved Sequences, Genome, Base Sequence, Genome, Human, 780105 Biological sciences, Computational Biology, Exons, Regulatory Elements, Human-chromosome-21, Introns, Alternative Splicing, Gene Expression Regulation, Genes, Mutation, Rna, Nucleic Acid Conformation, DNA, Intergenic, Chickens
Identification, 572, Mouse, Evolution, Molecular Sequence Data, Noncoding Sequences, Gene, Evolution, Molecular, Mice, C1, Dogs, Animals, Humans, 270202 Genome Structure, Conserved Sequence, Genetics & Heredity, Conserved Sequences, Genome, Base Sequence, Genome, Human, 780105 Biological sciences, Computational Biology, Exons, Regulatory Elements, Human-chromosome-21, Introns, Alternative Splicing, Gene Expression Regulation, Genes, Mutation, Rna, Nucleic Acid Conformation, DNA, Intergenic, Chickens
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