RNAi Extends Its Reach

descriptionPublicationkeyboard_double_arrow_right Article 22 Aug 2003 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 301, pages 1,060-1,061 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Marjori, Matzke; Antonius J M, Matzke;

doi: 10.1126/science.1089047

pmid: 12934001

RNAi Extends Its Reach

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Abstract

Genes are silenced when tiny regulatory RNAs bind to target messenger RNAs. But it is becoming clear that RNA interference goes beyond these interactions. In their perspective, [Matzke and Matzke][1] discuss recent work ([Schramke and Allshire][2]) that shows that the silencing pathway can induce heterochromatin formation in DNA that is normally euchromatic. The heterochromatin can spread laterally to silence nearby genes. [1]: http://www.sciencemag.org/cgi/content/full/301/5636/1060 [2]: http://www.sciencemag.org/cgi/content/short/301/5636/1069

Related Organizations

Austrian Academy of Sciences
Austria

Keywords

Retroelements, Chromosomal Proteins, Non-Histone, Terminal Repeat Sequences, Cell Cycle Proteins, Histone-Lysine N-Methyltransferase, Methyltransferases, Fungal Proteins, MicroRNAs, Heterochromatin, Schizosaccharomyces, Nucleic Acid Conformation, RNA Interference, Gene Silencing, Schizosaccharomyces pombe Proteins, RNA, Small Interfering

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