TRK Makes the Retrograde

Freda D. Miller; David R. Kaplan

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Article . 2002 . Peer-reviewed

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https://dx.doi.org/10.1126/sci...

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TRK Makes the Retrograde

descriptionPublicationkeyboard_double_arrow_right Article 22 Feb 2002 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 295, pages 1,471-1,473 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Freda D. Miller; David R. Kaplan;

doi: 10.1126/science.1069897

TRK Makes the Retrograde

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Abstract

Nerve growth factor binds to TrkA receptors on axon terminals, generating a survival signal that is propagated along the axon to the cell body of the neuron. In their Perspective, [Miller and Kaplan][1] discuss exciting new findings ([MacInnis and Campenot][2]) demonstrating that nerve growth factor does not have to be internalized with its receptor for the survival signal to be retrogradely transported along the axon to the neuronal cell body. [1]: http://www.sciencemag.org/cgi/content/full/295/5559/1471 [2]: http://www.sciencemag.org/cgi/content/short/295/5559/1536

Related Organizations

Montreal Neurological Institute and Hospital
Canada
McGill University
Canada

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