Intra- and Interspecific Variation in Primate Gene Expression Patterns
Copyright policy )Intra- and Interspecific Variation in Primate Gene Expression Patterns
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional gel electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.
- Biomedical Primate Research Centre Netherlands
- University of California, San Diego United States
- Charité - University Medicine Berlin Germany
- Max Planck Institute for Evolutionary Anthropology Germany
- Max Planck Institute for Multidisciplinary Sciences Germany
Male, DNA, Complementary, Pan troglodytes, Gene Expression Profiling, Brain, Gene Expression, Hominidae, Haplorhini, Biological Evolution, Macaca mulatta, Muridae, Mice, Liver, Organ Specificity, Pongo pygmaeus, Leukocytes, Animals, Humans, Female, Oligonucleotide Array Sequence Analysis
Male, DNA, Complementary, Pan troglodytes, Gene Expression Profiling, Brain, Gene Expression, Hominidae, Haplorhini, Biological Evolution, Macaca mulatta, Muridae, Mice, Liver, Organ Specificity, Pongo pygmaeus, Leukocytes, Animals, Humans, Female, Oligonucleotide Array Sequence Analysis
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