Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation
Copyright policy )Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca 2+ transients in dendrites and spines, but not at presynaptic sites. Pairing a weak burst of synaptic stimulation with a brief dendritic BDNF application caused an immediate and robust induction of LTP. LTP induction required activation of postsynaptic Ca 2+ channels and N -methyl- d -aspartate receptors and was prevented by the blockage of postsynaptic Ca 2+ transients. Thus, our results suggest that BDNF-mediated LTP is induced postsynaptically. Our finding that dendritic spines are the exclusive synaptic sites for rapid BDNF-evoked Ca 2+ signaling supports this conclusion.
Neurons, Mice, Inbred BALB C, Patch-Clamp Techniques, Brain-Derived Neurotrophic Factor, Long-Term Potentiation, Perforant Pathway, Action Potentials, Excitatory Postsynaptic Potentials, Dendrites, In Vitro Techniques, Receptors, N-Methyl-D-Aspartate, Axons, Mice, Dentate Gyrus, Synapses, Animals, Receptor, trkB, Calcium, Calcium Signaling
Neurons, Mice, Inbred BALB C, Patch-Clamp Techniques, Brain-Derived Neurotrophic Factor, Long-Term Potentiation, Perforant Pathway, Action Potentials, Excitatory Postsynaptic Potentials, Dendrites, In Vitro Techniques, Receptors, N-Methyl-D-Aspartate, Axons, Mice, Dentate Gyrus, Synapses, Animals, Receptor, trkB, Calcium, Calcium Signaling
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