Quantum emitters are a key component in photonic quantum technologies. Enhancing single-photon emission by engineering their photonic environment is essential for improving overall efficiency in quantum information processing. However, this enhancement is often limited by the need for ultraprecise emitter placement within conventional photonic cavities. Inspired by the fascinating physics of moiré pattern, we propose a multilayer moiré photonic crystal with a robust isolated flatband. Theoretical analysis reveals that, with nearly infinite photonic density of states, the moiré cavity simultaneously has a high Purcell factor and large tolerance over the emitter’s position, breaking the constraints of conventional cavities. We then experimentally demonstrate various cavity quantum electrodynamic phenomena with a quantum dot in moiré cavity. A large tuning range (up to 40-fold) of quantum dot’s radiative lifetime is achieved through strong Purcell enhancement and inhibition effects. Our findings open the door for moiré flatband cavity–enhanced quantum light sources and quantum nodes for the quantum internet.