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Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

descriptionPublicationkeyboard_double_arrow_right Article 16 Jul 2021 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 7 (eissn: 2375-2548, Copyright policy )
Authors: Miaoqing Hu; Fan Yang; Yawen Huang; Xin You; Desheng Liu; Shan Sun; Sen-Fang Sui;

doi: 10.1126/sciadv.abg3188

pmid: 34272236

pmc: PMC8284890

Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

Abstract

Structures of NPC1L1 reveal how NPC1L1 senses the cholesterol level by conformational changes of the sterol-sensing domain.

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Keywords

Cholesterol, Anticholesteremic Agents, Cryoelectron Microscopy, Azetidines, Humans, Membrane Proteins, Membrane Transport Proteins, Ezetimibe, Research Articles

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 55
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
55
Top 1%
Top 10%
Top 1%
Green
gold
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