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Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

descriptionPublicationkeyboard_double_arrow_right Article 27 Aug 2021 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 7 (eissn: 2375-2548, Copyright policy )
Authors: Yufeng Wang; Yajing Lyu; Kangsheng Tu; Qiuran Xu; Yongkang Yang; Shaima Salman; Nguyet Le; +6 Authors

doi: 10.1126/sciadv.abe3771

pmid: 34452909

pmc: PMC8397272

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

Abstract

Histone citrullination by PADI4 is required for hypoxia-induced gene expression.

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Keywords

Neovascularization, Pathologic, Hydrolases, Breast Neoplasms, Histones, Mice, Protein-Arginine Deiminase Type 4, Protein-Arginine Deiminases, Animals, Humans, Citrullination, Female, Hypoxia, Research Articles

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 72
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
72
Top 1%
Top 10%
Top 1%
Green
gold