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Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

descriptionPublicationkeyboard_double_arrow_right Article 22 May 2020 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 6 (eissn: 2375-2548, Copyright policy )Funded by:NIH | Molecular basis of axonal..., NIH | Defining the molecular me..., NIH | The Role the AAA+ Lon Pro... +3 projects
Authors: Mia Shin; Cristina Puchades; Ananya Asmita; Neha Puri; Eric Adjei; R. Luke Wiseman; A. Wali Karzai; +1 Authors

doi: 10.1126/sciadv.aba8404

pmid: 32490208

pmc: PMC7239648

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

Abstract

Substrate-free and -bound states of Lon reveal distinct operational modes used by the enzyme to process protein substrates.

Related Organizations
Keywords

Adenosine Triphosphate, Catalytic Domain, Cryoelectron Microscopy, Endopeptidases, Proteolysis, ATPases Associated with Diverse Cellular Activities, Research Articles, Peptide Hydrolases

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 74
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
74
Top 1%
Top 10%
Top 1%
Green
gold