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https://dx.doi.org/10.1126/sci...
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Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 07 Feb 2020 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 6 (eissn: 2375-2548, Copyright policy )
Authors: Sabine Aschenbrenner; Stefan M. Kallenberger; Mareike D. Hoffmann; Adrian Huck; Roland Eils; Dominik Niopek;

doi: 10.1126/sciadv.aay0187

pmid: 32076642

pmc: PMC7002122

Coupling Cas9 to artificial inhibitory domains enhances CRISPR-Cas9 target specificity

Abstract

Fusing attenuated anti-CRISPR proteins to Cas9 improves specificity via kinetic insulation of ON- and OFF-target editing events.

Related Organizations
Keywords

Gene Editing, Recombinant Fusion Proteins, Models, Theoretical, Cell Line, Substrate Specificity, Enzyme Activation, Kinetics, Genes, Reporter, Genetic Loci, CRISPR-Associated Protein 9, Gene Targeting, Humans, CRISPR-Cas Systems, Research Articles

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 59
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
59
Top 1%
Top 10%
Top 1%
Green
gold