GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2004 Australia English Publisher:Elsevier BVJournal:Drug Metabolism and Disposition, volume 32, pages 281-290 (issn: 0090-9556,

Copyright policy )

Authors: Wells, Peter G; Hansen, Antony J; Gregory, Philip A; Ishii, Yuji; Mackenzie, Peter Ian; Guillemette, Chantal; Chowdhury, Jayanta Roy; +4 Authors

doi: 10.1124/dmd.32.3.281

pmid: 14977861

handle: 2328/11418

GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE

- Summary
- Subjects
- Metrics

Abstract

This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.

Country

Australia

Related Organizations

Yeshiva University
United States
Virginia Commonwealth University
United States
Flinders University
Australia
University of Toronto
Canada
Université Laval
Canada

Keywords

Genetic Therapy, Xenobiotics, Glucuronides, Health, Pharmacogenetics, Risk Factors, Neoplasms, Animals, Humans, Disease, 1115 Pharmacology and Pharmaceutical Sciences, Glucuronosyltransferase

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	218
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%