In this response, the major criticisms of the target article are addressed. Terminology from the target article that may have caused some confusion is clarified. In particular, the tasks that have the basic features of muscle coordination, as identified in the target article, have been limited in scope. Anew metabolic optimization criterion suggested by Alexander (2000) is examined for its ability to predict muscle coordination in walking. Issues concerning the validation of muscle force predictions, the rules of muscle coordination, and the role of directional constraints in coordination of two-joint muscles are discussed. It is shown in particular that even in one-joint systems, the forces predicted by the criterion of Crowninshield and Brand (1981) depend upon the muscle moment arms and the physiological cross-sectional areas in much more complex ways than either previously assumed in the target article, or incorrectly derived by Herzog and Ait-Haddou (2000). It is concluded that the criterion of Crowninshield and Brand qualitatively predicts the basic coordination features of the major one- and two-joint muscles in a number of highly skilled, repetitive motor tasks performed by humans under predictable conditions and little demands on stability and accuracy. A possible functional significance of such muscle coordination may be the minimization of perceived effort, muscle fatigue, and/or energy expenditure.