High level sound exposure can cause substantial injury to the auditory system, motivating efforts to predict and prevent this injury. Measurement techniques using acoustic manikins are effective for low and moderate sound levels, but nonlinear effects in the middle ear and alternate sound transmission pathways to the inner ear limit their utility at higher sound pressure levels. Here, we describe results from a series of measurements made in cadaveric human ears conducted in our laboratory over the last several years. We quantified sound transmission to the inner ear by measuring the difference in sound pressure level across the cochlear partition near the base of the cochlea, which drives basilar membrane motion. We describe measurements quantifying sound transmission through the human middle ear, which is limited by suspensory ligaments for sounds above approximately 130 dB SPL, resulting in nonlinear (harmonic) distortion of sounds in the cochlea at higher sound pressure levels. Similarly, we describe observations of sound transmission to the cochlea via bone conduction from vibratory transducers, as well as high level sound and impulse noise/blast exposures. The implications of these measurements for hearing loss predictions, effectiveness of hearing protective devices, and injury mechanisms are discussed.