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Photoacoustic imaging demonstration

Authors: Murray S. Korman; Leah E. Burge;

Photoacoustic imaging demonstration

Abstract

Experiments [T. J. Allen and P. C. Beard, “High power visible light emitting diodes as pulsed excitation sources for biomedical photoacoustics,” Biomed. Opt. Express 7(4), 1260–1270 (2016)] describe the use of a visible light-emitting diode (LED) as an alternative to using a Q-switched Nd:YAG laser as a photoacoustic excitation (1 mJ pulse) source for below-the-surface vascular imaging. They describe the feasibility of using a low-cost LED, overdriven by a factor of 10 in current, with short pulses ∼200 ns operating at a 0.01% duty cycle to achieve ∼10 μJ in an imaging experiment involving hemoglobin absorption (wavelength of 623 nm). A version of the experiment is demonstrated where an SST-90R LED (λ = 620 nm, 18 A maximum CW current) is driven from a home-made MOSFET pulsed driver, capable of providing pulses up to 50 A. Our demonstration of photoacoustic tomography involves a ∼1cm diam LED beam illuminating three closely-spaced vertical 1.4 mm tubes filled with blood (35% haematocrit), mounted in an open acrylic water tank. An immersion transducer (3.5 MHz, cylindrically focused PZT with 60 dB gain) detects time-averaged photoacoustic signals versus rotation angle. Then back-projection imaging can construct a two-dimensional image.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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