The dominant mechanisms through which cavitation activity may lead to enhanced heating in tissue and tissue-like media with high-intensity focused ultrasound remain unclear. Previously, the authors have reported the results of experimental [J. Acoust. Soc. Am. 104 (A) (1998)] and numerical [ibid. 106 (A) (1999)] investigations which sought to understand the relationship between parameters relevant to the cavitation field, dominant heating mechanisms, and the magnitude of the enhanced heating effect. The model has since been extended to better account for heating from acoustic re-radiation. Results of expanded numerical simulations which incorporate bubble related heating source terms in an existing FDTD code designed to calculate temperature response as a function of the incident acoustic field are reported. Experiments aimed at manipulating the cavitation field to facilitate reproducibility and control are also reported. [Work supported by DARPA.]