Previous work on the chemical reactions caused by intense ultrasound waves in aqueous systems had raised the following question. Is the obtainable amount of chemical change of a slightly-soluble reactant (such as carbon tetrachloride) limited by the circumstance that at any given time only a small portion can be dissolved in the cavitating water? In the present work, an answer was sought through study of the ultrasonic splitting of carbon-halogen bonds in selected pairs of compounds. The two members of each pair were of similar molecular size, but one was soluble and the other was relatively insoluble; a typical pair was chloroacetic acid and chlorobutane. It was found experimentally that the soluble compound showed actually less chemical change than its insoluble analog upon irradiation in dilute aqueous systems under parallel conditions. Solubility, therefore, does not seem to be the limiting factor in determining the quantitative yield of a sonochemical reaction.