We analyze the interference of individual photons in two overlapping Mach–Zehnder interferometers joined via a common beam splitter. We show how two kinds of interference effects—single-photon Mach–Zehnder interference and two-photon Hong–Ou–Mandel interference—interfere with one another, partially canceling each other out. This configuration illustrates how quantum effects can combine nontrivially and, moreover, emphasizes that quantum interference happens at measurement. This work can serve as a bridge to more advanced quantum mechanical concepts, such as testing the predictions of quantum mechanics vs local realism.