Phototoxicity Of Rhodamine Dyes

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 17 Mar 1989Publisher:SPIEJournal:SPIE Proceedings, volume 997, page 48 (issn: 0277-786X,

Authors: Tayyaba Hasan; Norah Chen; Christopher R. Shea;

doi: 10.1117/12.960184

Phototoxicity Of Rhodamine Dyes

- Summary
- Metrics

Abstract

Rhodamine-123 (R123) and tetrabromo-R123 (TBR) have been evaluated in vitro as potential photosensitizers. R123 localizes selectively in mitochondria of MGH-V1 bladder carcinoma cells exposed to 10 pM R123 for 30 min, and under these conditions R123 is a weak photosensitizes. Incubation with R123 for longer times enhances its phototoxicity, and is associated with a modification of its intracellular localization. TBR is approximately 100 times more phototoxic than R123, as assessed either by 3H-thymidine uptake or vital staining. Actively proliferating cells are more sensitive to either R123 or TBR phototoxicity than are plateau-phase, confluent cultures.

Related Organizations

Harvard University
United States

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	3
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average