Medical image elastic registration is an important subject in medical image processing. Previous work has focused how to select the corresponding landmarks manually and then use adequate interpolating for gaining the elastic transformation. However, the landmarks extraction is always prone to error, which could influence on the registration results. And localizing the landmarks manually is also difficult and time-consuming. We used Multiquadric method with smooth character, thereby , utilized a semi-automatic method to extract the landmarks .Combining these two steps, we proposed an accurate, fast and more robust registration method ,and obtained the satisfactory results.