The minimum possible uncertainty when estimating a parameter, in this case transmission, is bounded by the quantum Cramer-Rao bound (QCRB). This bound is independent of the measurement technique and as result can be used to quantify how close a measurement is to the optimal one for a given system and probing state, as an optimal measurement saturates the QCRB. The ability to perform transmission measurements through an optical system at the QCRB can lead to enhancements in the calibration of optimal states for interferometers, the characterization of high efficiency photodetectors, or the sensitivity of sensing devices based on transmission, such as plasmonic sensors or spectroscopy. We show theoretically that the ultimate sensitivity limit per photon in the estimation of transmission, achievable with Fock states or vacuum two-mode squeezed states (vTMSS), can be approached through the use of bright quantum states of light, such as bright single-mode squeezed states (bSMSS) or bright two-mode squeezed states (bTMSS). The use of bright quantum states has the advantage that they can be generated with a significantly larger number of photons, which leads to an absolute sensitivity that can be many orders of magnitude larger than the one achieved with Fock states or vTMSS. We identify a measurement strategy that saturates the QCRB for these bright quantum states and shown experimentally that transmission estimation at the QCRB can be achieved with bTMSS through optimized intensity difference measurements.