Optical coherence tomography of malignancy in hamster cheek pouches
Copyright policy )Optical coherence tomography of malignancy in hamster cheek pouches
Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-microm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis.
- University of California, Irvine United States
- University of California, San Francisco United States
9,10-Dimethyl-1,2-benzanthracene, Biomedical Engineering, 610, diagnostic, Bioengineering, Optical Physics, Atomic, Sensitivity and Specificity, Engineering, Rare Diseases, malignant, Opthalmology and Optometry, Cricetinae, 2-benzanthracene, Animals, Single-Blind Method, molecular and optical physics, Tomography, 9, Cancer, Biomedical and Clinical Sciences, Mesocricetus, airway injury, Reproducibility of Results, Optics, Ophthalmology and optometry, oral cancer, 10-Dimethyl-1, laser, Optical Coherence, Biomedical Imaging, Mouth Neoplasms, Biomedical engineering, Tomography, Optical Coherence
9,10-Dimethyl-1,2-benzanthracene, Biomedical Engineering, 610, diagnostic, Bioengineering, Optical Physics, Atomic, Sensitivity and Specificity, Engineering, Rare Diseases, malignant, Opthalmology and Optometry, Cricetinae, 2-benzanthracene, Animals, Single-Blind Method, molecular and optical physics, Tomography, 9, Cancer, Biomedical and Clinical Sciences, Mesocricetus, airway injury, Reproducibility of Results, Optics, Ophthalmology and optometry, oral cancer, 10-Dimethyl-1, laser, Optical Coherence, Biomedical Imaging, Mouth Neoplasms, Biomedical engineering, Tomography, Optical Coherence
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