The construction of antibacterial surfaces is an efficient way to respond to the problem of microbial contamination. In this review, we first describe the formation process and characteristics of microbial contamination and the current research status of antibacterial surfaces. Then, the passive antiadhesion, active killing, and combination construction strategies of the antibacterial surface are discussed in detail. Based on different antibacterial mechanisms and existing problems of current antibacterial strategies, we then discuss the future development trends of the next generation of antibacterial surfaces.