As part of an ongoing effort to characterize the mechanical behavior of biological tissues in the cryogenic temperature range, the current study focuses on the thermal expansion measurements of cryoprotective agents. This study focuses particularly on the upper part of the cryogenic temperature range, where the cryoprotectant behaves like low viscous liquid at all practical cooling rates. A new experimental apparatus for thermal expansion measurements is presented in this report. This report includes thermal expansion measurements of the cryoprotectant mixtures DP6 and VS55, and comparison with data from the literature on DMSO solutions.