The multihead weigher is a complex machine which has to be properly configured and managed by taking into account the uncertainty of the load cells. Specifically, this paper focuses on the configuration problem of the multihead weigher First an objective function is proposed. This function considers both the costs of “non conforming” packages (i.e. packages that have to be scrapped or reworked because their weight is below the law lower limit) and the cost of extra product (i.e. cost of material that exceeds the target weight). Secondly, the paper presents an approach to select the average weight to be set for each hopper by combining a RSM (Response Surface Methodology) and a multihead weighing machine simulator. The performance of the proposed approach is presented and discussed.