Abstract The objective of this paper is to describe the design and function of the multisplit ventilator system (MSVS); an airflow apparatus that enables physicians to provide individualized, isolated ventilation to up to four patients using a single ventilator. Method: The study design is laboratory assessment of the ability of the MSVS to decouple the pressures and resulting tidal volumes between patient limbs in response to adverse extubation (disconnection) or endotracheal tube occlusion of one of the patients in the system. We compare the airflow decoupling of the MSVS against an existing unregulated split ventilator system (USVS) design over eight prototypical patient pairs. Simulated patient prototypes of varying size, minute ventilation requirement, and positive end-expiratory pressure (PEEP) requirement were employed. Result: Respiratory support was developed for varying simulated patient pairs using the MSVS and a USVS. The results demonstrate that patients supported with the MSVS showed significantly smaller changes to tidal volume and PEEP after extubation events, and tidal volume after occlusion events. Conclusion: It was found that the MSVS as a regulated, shared ventilator system effectively buffered simulated patients from clinical changes occurring to another patient connected to the split ventilator. This decoupling ability resulted in significantly smaller changes in delivered support when compared to existing USVS designs, which is an important patient safety consideration if deciding to support multiple patients with a single ventilator.