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Article . 2012
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Article . 2012 . Peer-reviewed
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Cerebellar theta burst stimulation impairs eyeblink classical conditioning

Authors: Hoffland, Britt S.; Bologna, Matteo; Kassavetis, Panagiotis; Teo, James T. H.; Rothwell, John C.; Yeo, Christopher H.; van de Warrenburg, Bart P.; +1 Authors

Cerebellar theta burst stimulation impairs eyeblink classical conditioning

Abstract

Key points  Theta burst stimulation (TBS) protocols of repetitive transcranial magnetic stimulation (rTMS) have after‐effects on excitability of motor areas thought to be due to LTP‐ and LTD‐like processes at cortical synapses. TBS protocols have significant advantages over other rTMS techniques in time and intensities used. Eyeblink classical conditioning (EBCC) is a form of associative motor learning in which paired presentation of a conditioned (CS) and unconditioned stimulus (US) leads to the production of a conditioned eyeblink response (CR). EBCC, with its heavy dependence on cerebellar function, is an ideal protocol with which to assess and potentially quantify the possible influence of TBS on the cerebellum. We show that cerebellar TBS has clear effects on EBCC in humans, providing evidence that TBS can influence cerebellar function despite the low intensities of stimulation used and the anatomical constraints of the posterior fossa.

Countries
Italy, Netherlands
Keywords

Adult, Male, Blinking, DCN MP - Plasticity and memory, Conditioning, Classical, Transcranial Magnetic Stimulation, Young Adult, Cerebellum, Adult; Blinking; Cerebellum; Conditioning, Classical; Female; Humans; Male; Young Adult; Transcranial Magnetic Stimulation; Physiology, Humans, Female, 111 000 Intention & Action

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    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
57
Top 10%
Top 10%
Top 10%
Green
bronze