ABSTRACT Gastric dilatation‐volvulus (GDV) was diagnosed in four adult guinea pigs with histories of lethargy and progressive hyporexia. Clinical examination varied between cases and was not specific for gastrointestinal disease. CT revealed a severely gas‐dilated and malpositioned stomach in all cases. In three guinea pigs, a “whirl sign” was centered around the esophagus. Whole body CT facilitated the detection of significant concurrent pathology such as a splenic mass, obstructive ureterolithiasis, and aspiration pneumonia, leading to euthanasia in two cases. One guinea pig was successfully managed with orogastric tubing. One guinea pig had chronic signs of abdominal disease, which is rarely documented in cases of GDV. Whilst abdominal radiographs are often considered diagnostic for GDV in guinea pigs, CT may facilitate a more comprehensive overview of the condition and any significant comorbidities.