ABSTRACTBackgroundSince the release of chewable flavored oclacitinib, household pets are ingesting larger quantities and are experiencing signs of toxicosis that have not been noted previously.Key FindingsReports of intoxication have included gastrointestinal signs (vomiting, diarrhea, abdominal pain), cardiovascular signs (rhythm disturbances, hypotension, new onset heart murmur), CNS signs (lethargy, dull mentation, elevated nictitans), acute kidney injury in both dogs and cats, hepatotoxicity, and death.SignificanceWhen overdoses occur with meaningful clinical signs, clinicians are urged to provide proactive monitoring and treatment. Consultation with a poison control center and adverse event reporting to the manufacturer and the Food and Drug Administration are recommended.