BackgroundThere are few licensed options for the treatment of canine sarcoptic mange.ObjectiveTo evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.AnimalsSeventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings.MethodsA single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month.ResultsBy Day 14 post‐treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = −0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14–21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28.ConclusionFluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.