AbstractBackgroundTherapeutic phlebotomy (TP) is a well‐established medical intervention that evolved from the historical practice of bloodletting.MethodsPatients who require TP are not infrequently told by their health‐care providers to “just go donate blood,” but TP should always be offered in the context of a prescribed course of therapy. Providers can prescribe a course of TP for a number of indications, including hereditary hemochromatosis, polycythemia vera, iron overload, and testosterone replacement therapy.ResultsA course of prescribed TP specifies that patients can be phlebotomized more frequently than volunteer blood donors and reassures patients that TP is being performed per the orders of their provider. Prescribed TP also facilitates two‐way communication between the referring provider and the transfusion medicine (TM) physician overseeing the TP. The College of American Pathologists TM checklist describes several requirements regarding the documentation and performance of TP, and electronic medical record systems can be used to demonstrate compliance with these requirements.ConclusionsTM physicians should discuss the advantages of prescribing TP with providers who mutually care for patients requiring this intervention.