Retromer and the cation‐independent mannose 6‐phosphate receptor—Time for a trial separation?
Copyright policy )Retromer and the cation‐independent mannose 6‐phosphate receptor—Time for a trial separation?
The retromer cargo‐selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome‐to‐Golgi retrieval of the cation‐independent mannose 6‐phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this long‐established theory. Here, the evidence for and against a role for the retromer CSC in CIMPR endosome‐to‐Golgi retrieval is examined in the light of the new data that the SNX‐BAR dimer is actually responsible for CIMPR retrieval.
- University of Cambridge United Kingdom
- Addenbrooke's Hospital United Kingdom
- UNIVERSITY OF CAMBRIDGE
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
CIMPR, cargo-selection, SNX-BAR, endosome-to-Golgi retrieval, Vesicular Transport Proteins, Golgi Apparatus, sorting motif, Endosomes, Protein Transport, Perspective, Retromer, Humans, Carrier Proteins, trans-Golgi Network
CIMPR, cargo-selection, SNX-BAR, endosome-to-Golgi retrieval, Vesicular Transport Proteins, Golgi Apparatus, sorting motif, Endosomes, Protein Transport, Perspective, Retromer, Humans, Carrier Proteins, trans-Golgi Network
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).29 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!