Full-length genome sequence analysis of an avian leukosis virus subgroup J (ALV-J) as contaminant in live poultry vaccine: The commercial live vaccines might be a potential route for ALV-J transmission
Copyright policy )Full-length genome sequence analysis of an avian leukosis virus subgroup J (ALV-J) as contaminant in live poultry vaccine: The commercial live vaccines might be a potential route for ALV-J transmission
One avian leukosis virus subgroup J (ALV-J) strain was isolated from 67 commercial live poultry vaccines produced by various manufacturers during 2013-2016 in China. The complete genomes of the isolate were sequenced and it was found that the genes gag and pol of the strain were relatively conservative, while the gp85 gene of the strain GX14YYA1 had the highest similarities with a field strain GX14ZS14, which was isolated from the chickens of a farm that had once used the same vaccine as the one found to be contaminated with the GX14YYA1. This is the first report of ALV-J contaminant in live poultry vaccine in China. Our finding demonstrates that vaccination of the commercial live vaccines might be a potential new route for ALV-J transmission in chickens and highlights the need for more extensive monitoring of the commercial live vaccines in China.
- Chinese Academy of Sciences China (People's Republic of)
- Guangxi University China (People's Republic of)
- Shanghai Institute of Nutrition and Health China (People's Republic of)
China, Avian Leukosis Virus, Base Sequence, Vaccination, Enzyme-Linked Immunosorbent Assay, Viral Vaccines, Genome, Viral, Sequence Analysis, DNA, Polymerase Chain Reaction, Poultry, Avian Leukosis, Animals, Drug Contamination, Chickens, Sequence Analysis, Poultry Diseases
China, Avian Leukosis Virus, Base Sequence, Vaccination, Enzyme-Linked Immunosorbent Assay, Viral Vaccines, Genome, Viral, Sequence Analysis, DNA, Polymerase Chain Reaction, Poultry, Avian Leukosis, Animals, Drug Contamination, Chickens, Sequence Analysis, Poultry Diseases
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