
SummaryBackgroundUltraviolet radiation (UVR) is a well‐known exacerbating factor for cutaneous lupus erythematosus (CLE), with photosensitivity comprising one of the American College of Rheumatology (ACR) diagnostic criteria for systemic lupus erythematosus (SLE). However, discerning true photosensitivity in this population is difficult due to the broad language utilized by the ACR and the delayed‐onset nature of photosensitive lupus lesions.AimsThe objective of this report is to provide a review of photosensitivity, photoprovocation, and phototherapy in the context of CLE patients.MethodsA literature review in PubMed was conducted using the terms ‘ultraviolet light,’ ‘lupus erythematosus,’ ‘photoprovocation,’ or ‘photosensitivity.’ResultsSelf‐patient reporting of photosensitivity and the broad definition of photosensitivity have led to the wide range of photosensitivity rates in CLE patients. Photoprovocation testing provides a more objective method to measure photosensitivity, but even these trials demonstrate significant differences due to protocol variations. Despite UVR's deleterious effect on lupus patients, ultraviolet A (UVA)‐1 may have therapeutic benefits as shown by observations on murine models and human lupus subjects.ConclusionsAccurately discerning photosensitivity has diagnostic implications for SLE and provides motivation for greater patient adherence to photoprotective methods.
Disease Models, Animal, Mice, Ultraviolet Rays, Lupus Erythematosus, Cutaneous, Animals, Humans, Photosensitivity Disorders
Disease Models, Animal, Mice, Ultraviolet Rays, Lupus Erythematosus, Cutaneous, Animals, Humans, Photosensitivity Disorders
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 64 | |
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| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
