Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA
Copyright policy )Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA
Abstract Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are typically mediated by autoantibodies targeting the NC16A region of BP180; however, a small subset of adult patient sera react to other regions of the protein. The incidence of a similar occurrence in juvenile BP is unknown. This case of juvenile BP with a negative BP180 ELISA highlights diagnostic pitfalls that can lead to a delay in the correct diagnosis in the pediatric population.
- University of Iowa Health Care United States
Male, Case Report, Enzyme-Linked Immunosorbent Assay, Non-Fibrillar Collagens, Autoantigens, Pemphigoid, Bullous, Humans, Female, Child, Collagen Type XVII, Autoantibodies
Male, Case Report, Enzyme-Linked Immunosorbent Assay, Non-Fibrillar Collagens, Autoantigens, Pemphigoid, Bullous, Humans, Female, Child, Collagen Type XVII, Autoantibodies
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