AbstractInfectious panniculitis from hematogenous spread is uncommon and usually occurs in immunocompromised patients. Dissemination of gram‐positive organisms to the subcutaneous tissue is rare with only several reports of disseminated panniculitis caused by Streptococcal species. We report a case of an immunocompetent 2‐year‐old boy presenting with diffuse neutrophilic panniculitis arising from methicillin‐resistant Staphylococcus aureus septicemia. This case represents a highly atypical manifestation of severe MRSA infection and serves as a reminder to consider MRSA as a cause of disseminated neutrophilic panniculitis, particularly in high‐risk populations.