Type 2 inflammation in cystic fibrosis: New insights
Copyright policy )Type 2 inflammation in cystic fibrosis: New insights
AbstractRecently, type 2 inflammation has been recognized as one of the most critical factors participating in the pathogenesis of cystic fibrosis (CF). On the one hand, type 2 inflammation restores tissue homeostasis and contributes to the resolution of inflammation following an injury. On the other hand, type 2 response‐activated immune cells may become dysregulated or chronically activated, causing tissue fibrosis. Among the type 2 cytokine‐driven inflammatory pathways, the transforming growth factor β (TGFβ), interleukin (IL)‐17, IL‐33, and IL‐13 have been identified as essential mediators in patients suffering from CF. Given their critical role, we firmly believe that an adequate comprehension of the type 2‐mediated pathways can identify attractive targets to decrease pharmacologically the inflammation and fibrosis occurring in the pulmonary tissue of patients suffering from CF.
- University of Pavia Italy
- Policlinico San Matteo Fondazione Italy
- University of Messina Italy
- University of Catania Italy
Inflammation, Cystic Fibrosis, adult, type 2 inflammation, adult, children, cystic fibrosis, tissue fibrosis, type 2 inflammation, Cytokines, Humans, Inflammation, Inflammation Mediators, Lung, Cystic Fibrosis, 610, cystic fibrosis, tissue fibrosi, Special Issue: 2021 Update From The Italian Society Of Pediatric Allergy And Immunology, children, tissue fibrosis, 616, Cytokines, Humans, Inflammation Mediators, Cytokine, Inflammation Mediator, Lung, cystic fibrosi, Human
Inflammation, Cystic Fibrosis, adult, type 2 inflammation, adult, children, cystic fibrosis, tissue fibrosis, type 2 inflammation, Cytokines, Humans, Inflammation, Inflammation Mediators, Lung, Cystic Fibrosis, 610, cystic fibrosis, tissue fibrosi, Special Issue: 2021 Update From The Italian Society Of Pediatric Allergy And Immunology, children, tissue fibrosis, 616, Cytokines, Humans, Inflammation Mediators, Cytokine, Inflammation Mediator, Lung, cystic fibrosi, Human
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