AbstractIntroductionThe increasing number of cardiac implantable electronic device complications represents a current problem. Abandoned leads are difficult to manage, even because indications to transvenous lead extraction (TLE) cannot be generalized. The aim of the study was to assess the late consequences of previous abandoned leads.MethodsWe did a retrospective analysis of clinical data from 3,810 patients undergoing TLE in two high‐volume centers (Poland and Italy) in the years 2006–2017. In order to evaluate the effects of lead abandonment, the patients were divided into a group of 582 (15.3%) subjects with abandoned leads (AL) and a group of 3,228 (84.7%) subjects with functional leads (FL).ResultsInfective indications to TLE were predominant in the AL group (61.34% vs 43.4%; P < 0.001). AL was associated with a higher number of leads per patient, longer lead dwell times, more frequent venous occlusion, higher probability of intracardiac lead abrasion, and tricuspid regurgitation (P < 0.001 for all factors). The presence of AL was connected with more frequent technical complications of TLE (odds ratio [OR] 1.617; confidence interval [CI] 1.412–1.852; P = 0.000), lower procedural success rate (OR 0.270; CI 0.199–0.363; P = 0.000), and with higher mortality rate during 3.518 years of follow‐up [hazard ratio 1.286; 95% CI (1.062–1.558), P = 0.010].ConclusionsPresence of previously abandoned leads was associated with the risk of device infections, technical problems during subsequent lead extraction, dysfunction of tricuspid valve, and worse long‐term outcomes.