AbstractPeriodontitis is an oral inflammatory disease characterised by the destruction of periodontal soft tissue and alveolar bone resorption, mainly triggered by plaque microbial infection. Pyroptosis is an inflammatory form of programmed cell death mediated by the pore‐forming gasdermin proteins, which resist the invasion of pathogens into the body's immune system. Many studies have found that pyroptosis is closely related to the occurrence and development of periodontitis. At present, most of these studies focused on the canonical pathway mediated by caspase‐1. Moreover, Gram‐negative bacteria's lipopolysaccharide has been shown to activate a new form of the non‐canonical inflammasome by directly binding to human caspase‐4/5 and mouse caspase‐11 in the cytosol. However, most of the functions of non‐canonical inflammasome are still gradually being studied. Therefore, in this review, we have summarised and analysed the existence and regulation mechanism of the non‐canonical inflammasome in periodontitis.