Abstract Objectives To investigate the association between oral lichen planu(OLP) and anxiety. Subjects and Methods This study included 174 OLP patients and 174 healthy controls. We assessed anxiety by Self‐rating Anxiety Scale (SAS) and recorded OLP lesion type and severity. t test and analysis of variance were applied for continuous variants and chi‐square test was performed for categorical variants. Multiple linear regression and logistic regression analysis were used for multi‐variable analysis. Results he SAS score of OLP patients was higher than that of healthy individuals. There was no significant difference in SAS score between the OLP subgroups, obtained according to age, type, and severity, respectively. Multiple linear regression analysis showed gender was the only factor that affected the SAS score of OLP patients. Compared with weakly anxiety‐related groups, the SAS score and female ratio of highly anxiety‐related group were obviously higher. Logistic regression analysis demonstrated that males were less exposed to highly anxiety‐related types than females. Conclusions OLP patients tend to be more anxious compared with healthy individuals, and female patients are more anxious than male patients. There might be two types of OLP patients: weakly anxiety‐related or highly anxiety‐related. These results highlight the significance of psychological counseling in OLP disease management.