Abstract In a recent study published in Proceedings of the National Academy of Sciences of the United States of America, Chen and collaborators (2015), aiming to discover predictive markers with impact on treatment and survival of patients with oral squamous cell carcinoma (OSCC), described an important role of the transmembrane receptor B7 homolog 3 (B7-H3), also known as CD276 and B7RP-2, in OSCCs. Besides the overexpression of this protein, the results highlight differences in the N-glycan structure of this glycoprotein between normal and tumor cell lines, suggesting a possible mechanism of explanation of its function in both cancer and immune response. This article is protected by copyright. All rights reserved.