In patients with laryngopharygeal reflux (LPR), gastric contents exhibit retrograde flow into the upper aero‐digestive tract, causing extraesophageal symptoms including chronic cough, hoarseness, indigestion, difficulty swallowing, globus pharyngis, and asthma. The following on laryngopharyngeal reflux includes commentaries on the use of patient‐completed questionaires and anti‐human pepsin antibodies and other non‐invasive tests in diagnosis; the role of pepsin and acid in the etiologies of laryngeal cancers; and the application of proton pump inhibitor (PPI) therapy for the treatment of LPR.