AbstractNurses increasingly interact with health information systems (HIS) in their daily work. This article examines how the problems that they confront in that interaction can be understood through the theoretical concepts of technical rationality and an ethic of care. The findings are based on a qualitative study of nurses in one Swedish hospital. They suggest that HIS did not support the holistic care of patients, and were not adapted to the varied and often urgent situations that nurses faced in their daily work, leaving them feeling isolated with their problems. In summary, HIS were found to serve the administrative aims of a hospital organisation, based on technical rationality, rather than supporting patients' needs as seen from an ethics of care perspective. The contribution of the study is to show how the use of these two conceptual tools connects nurses' daily problems with HIS to more fundamental issues about the values upon which healthcare is grounded.