The role of dipeptide‐repeat protein pathology in C9orf72 mutation cases

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 30 Mar 2016 English Publisher:WileyJournal:Neuropathology and Applied Neurobiology, volume 42, pages 217-219 (issn: 0305-1846, eissn: 1365-2990,

Copyright policy )

Authors: I R A, Mackenzie;

doi: 10.1111/nan.12296

pmid: 26577056

The role of dipeptide‐repeat protein pathology in C9orf72 mutation cases

- Summary
- Subjects
- Metrics

Abstract

Repeat‐associated non‐ATG initiated (RAN) translation leads to the generation and intracellular accumulation of five different dipeptides in cases of C9orf72 mutation. Understanding the potential toxicity of these dipeptides is a focus of active investigation.

Related Organizations

University of British Columbia
Canada
Vancouver General Hospital
Canada
Vancouver Hospital and Health Sciences Centre
Canada
Vancouver Coastal Health
Canada

Keywords

DNA Repeat Expansion, C9orf72 Protein, Animals, Humans, Proteins, Dipeptides, Frontotemporal Lobar Degeneration, Motor Neuron Disease

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average