Abstract Background and Purpose Diffusion kurtosis imaging (DKI) is an advanced technique more specific to irreversible ischemic injury than conventional diffusion‐weighted imaging (DWI). However, its clinical translation has been limited by a long acquisition time and complex postprocessing. Methods A fast DKI sequence (3 minutes) was implemented on a 3T MRI (Siemens Trio) and piloted as part of an inpatient brain MRI protocol. Mean kurtosis (MK) and mean diffusivity (MD) maps were postprocessed automatically at the scanner console and sent to the Picture Archiving and Communications System. We retrospectively reviewed consecutive patients in a 5‐month period with acute ischemic stroke due to large vessel occlusion. MK and MD of the ischemic infarcts and contralateral normal brain were measured, and lesion volumes were measured in large infarcts using semiautomated segmentation. Results Twenty‐two patients were included in the study (median age 66). The median time from last known well to MRI was 37 hours. MD and MK maps were successfully processed and demonstrated acute infarction in concordance with DWI in all cases. Infarcted regions had higher MK and lower MD compared to contralateral normal‐appearing regions. MK lesion volume was significantly smaller than MD volume. Conclusion In this pilot study, we demonstrated the feasibility of incorporating a fast DKI sequence into a clinical MRI protocol. Acute infarcts were depicted on kurtosis maps, and MK lesion volumes were smaller than MD, in accordance with prior works. Future studies are needed to determine the role of DKI in acute stroke treatment selection and prognostication.