AbstractObjectiveThis study evaluated the influence of over‐the‐counter agents on the maintenance of color and microhardness of the enamel after home bleaching protocol.Materials and methodsSpecimens of bovine teeth (6 × 6 × 2 mm) were prepared, and color (Easyshade, VITA) and microhardness (HMV‐2, Shimadzu) readings were performed. All the specimens were bleached using 22% carbamide peroxide (22%CP), except for the control group, and then separated into seven groups (n = 10) according to the interaction of toothpaste (whitening, conventional, and whitening with peroxide) and mouth rinse (whitening and conventional). The study simulated 1 year of toothbrushing (Pepsodent, MAVTEC) and mouth rinse by immersion. After that, final color and microhardness measurements were performed. Data were analyzed by one‐way ANOVA, Tukey's test (P < .05).ResultsThe group submitted to 22%CP + whitening toothpaste + whitening mouth rinse showed higher color maintenance (P < .05) than the control group. The perception of whitening of teeth (ΔWID) was higher than the color change (ΔE00). There was a decrease in microhardness after treatment with 22%CP + conventional toothpaste + whitening mouth rinse.ConclusionsOver‐the‐counter products can help with the maintenance of tooth whitening after bleaching with carbamide peroxide; however, special attention should be given since the association of products can also reduce the microhardness of the dental enamel.Clinical significanceThe association between whitening toothpastes and mouth rinses might be beneficial for maintaining color during 1 year after bleaching treatment.